Endocrine Abstracts

Background: Primary empty sella (ES) can be asymptomatic or associated with endocrine and neurological alterations, such as visual defects. Studies in a large number of patients is still lacking.Objective: To study visual deficit in ES and its relationship with hormonal status.Material and Methods: We recorded visual evoked potentials (VEP) by white/black, red/black, blue/black patterns. Isoluminance between red and blue checks all...

Background: 131I-norcholesterol scintigraphy (INCS) is currently not considered a main confirmatory and localizing study in primary aldosteronism (PA), however few recent data is available. On the other hand, adrenal venous sampling (AVS) is technically difficult, and may also lead to erroneuos diagnosis.Aim: To describe the performance of INCS, done under dexamethasone (DXM) supression, in daily practice.Patients and methods: Retr...

Introduction: The last World Health Organization (WHO) 2016 classification of Pituitary Tumours recommends the determination of transcription factors. During the last few years, silent variants of the main pituitary tumours (PTs) have been described. The mechanisms of silencing of these tumors are still unknown. POU1F1 (Pit1) encodes a member of the POU family of transcription factors that has a relevant role in the differentiation, proliferation and survival of three...

IntroductionClinical guidelines for the prevention and treatment of vitamin D deficiency in adults were formulated and implemented into clinical practice by the Russian association of endocrinologists in 2014. While having multiple health benefits, in some cases, prescribing vitamin D supplements may be accompanied by its toxicity, which has various manifestations and exert potentially dangerous health consequences.Aim<p class=...

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

Background and Aims: Diabetes is often associated with an increased severity and mortality in COVID-19 patients. Possible mechanisms include hyperglycemia-induced impaired immune response, characterized by a state of chronic low-grade inflammation. Objectives: evaluate if diabetes and glycemic control were related to the severity of disease and mortality in hospitalized COVID-19 patients.Methods: We conducted a retrospective case control study that inclu...

Background: Obesity represents a threatening worldwide epidemic but, beyond the guidelines recommendations, its modalities of treatment in the medical community appear as variable and not clearly defined. Aim of our survey was to assess the present real-world approach to obesity management in Italy.Methods: Online anonymous survey among the 2248 members of the Italian Association of Clinical Endocrinologists (AME). The survey included 8 questions about d...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...

Introduction: Type 2 diabetes mellitus (DM2) is the most common disease in the spectrum of metabolic disorders, with its prevalence increasing significantly in recent years. It is estimated that by 2035, 592 million people will have type 2 diabetes. People with type DM2 have high rates of depression and a quality of life that is poorer than that of the general population. Another important factor in the quality of life of people with DM2 is the compliance of patients with the ...

Introduction: Diabetes mellitus (DM) is a disease that shows a rapid increase over the recent years and is a major cause of morbidity and mortality. Thus new ways of prevention and treatment are needed and constantly being developed. As a lifelong challenge, DM is likely to affect one’s life in a variety of ways. It requires daily planning and decision making. Self-care is a vital component of the disease. Knowledge consists of information about the disease and its manage...